Authors: Nehad A Mossad Enas H Mahmoud Enas A Osman Sherif H Mahmoud Hend I Shousha
Publish Date: 2014/08/17
Volume: 35, Issue: 11, Pages: 11559-11564
Abstract
Hepatocellular carcinoma HCC surveillance lacks a reliable biomarker Alphafetoprotein AFP is the most widely used However not all HCCs secrete AFP AFP may be elevated with cirrhosis in the absence of HCC Serum alphalfucosidase AFU and squamous cell carcinoma antigenimmunoglobulin M complex SCCAIgM were found to be useful markers in diagnosing HCC SCCAIgM and AFU were assessed by ELISA technique AFP was measured by enzyme chemiluminescence in serum of 40 patients with HCC 30 patients with liver cirrhosis and 20 healthy control participants to compare their accuracy in early diagnosis of HCC Serum SCCAIgM and AFU levels were significantly elevated in HCC group compared to cirrhotic group P value 0001 and 0001 respectively Receiver operating characteristic curve showed the optimal cutoff value for SCCAIgM was 233 AU/ml with sensitivity 875 and specificity 66 and for AFU was 25 U/L with sensitivity 875 and specificity 98 AFP cutoff value was 48 ng/mL with sensitivity of 70 and specificity of 533 The simultaneous determination of AFP and SCCAIgM activity increased the sensitivity to 925 and specificity to 621 There were positive significant correlations between SCCAIgM and each of AFU r = 0296 P = 0005 and AFP r = 0284 P = 0007 and no correlation between AFP and AFU All markers did not correlate with the tumor size or affected by the Child score The significant difference between SCCAIgM and AFU levels among HCC and cirrhotic patients suggests their use as potential diagnostic tools and allows identifying a new group of HCC patients even in the absence of elevated AFP
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