Authors: Hongbo Tang Xinggu Luo Juan Li Yi Zhou Yanmei Li Lijuan Song Xiaowen Zhang Tao Chen
Publish Date: 2016/02/08
Volume: 37, Issue: 8, Pages: 10563-10569
Abstract
Metabolism alteration is one of the hallmarks of cancer cells Although several studies have demonstrated that glycolysis played important roles in the progression of nasopharyngeal carcinoma NPC the functions of specific metabolismassociated genes remain largely unknown In this study it was found that Pyruvate dehydrogenase B PDHB which catalyzed the conversion of pyruvate to AcetylCoA was downregulated in NPC cells Forced expression of PDHB in NPC cells inhibited cell growth and migration while knocking down the expression of PDHB promoted the growth migration and tumorigenesis of NPC cells Mechanism study showed that PDHB inhibited ERK signaling and cell growth driven by RasV12 Collectively our study demonstrated the suppressive roles of PDHB in the progression of NPC and restoring the function of PDHB might be a promising strategy for NPC therapyThis work was supported by the grants of Chen T from the Medical Research Foundation of Guangdong Provincial Health and Family Planning Commission A2015005 the National Natural Science Foundation of China 81402963 and the First Affiliated Hospital of Guangzhou Medical University the “Young Elite Talents Program” and the “Science and Technology Support Projects”
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