Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Tumor Biol

Search In Journal Title:

Abbravation: Tumor Biology

Search In Journal Abbravation:

Publisher

Springer Netherlands

Search In Publisher:

DOI

10.1016/j.addma.2016.09.001

Search In DOI:

ISSN

1423-0380

Search In ISSN:
Search In Title Of Papers:

FAM172A is a tumor suppressor in colorectal carcin

Authors: Chunhui Cui Lili Ye Zonghai Huang Shuxin Huang Hao Liu Jinlong Yu
Publish Date: 2015/12/04
Volume: 37, Issue: 5, Pages: 6501-6510
PDF Link

Abstract

The present study was designed to elucidate the regulatory role of a novel protein FAM172A in carcinogenesis of colorectal carcinoma CRC Investigation of clinical samples using Western blotting showed that expression of FAM172A is significantly lower in cancerous tissues than in adjacent tissues Furthermore we constructed in vitro model for continuous overexpression and silencing of FAM172A with a retroviral vector system FAM172A suppressed the proliferative and invasive potentials of LOVO cells as shown in MTT test transwell migration assay wound healing assay 3Dculture morphologic study and xenograft experiment RTPCR and Western blotting showed that FAM172A overexpression inhibited expressions of Cyclin D1 CDK2 MMP2 MMP9 PERK elF2α ATF6 XBP1 and GRP78 while FAM172A silencing induced their expressions FAM172A might regulate ERS through PERKelF2α ATF6XBP1GRP78 signal pathway The results implicated that FAM172A functioned as a tumor suppressor in colorectal carcinomaThe protocol used in this study had been reviewed and approved by Medical Ethics Committee of Zhujiang Hospital Southern Medical University All participating patients were formally informed for the purpose of using their samples in this study and a letter of consent had been signed by every patient participated

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. MicroRNA-608 acts as a prognostic marker and inhibits the cell proliferation in hepatocellular carcinoma by macrophage migration inhibitory factor
  2. Interpretation of immunohistochemistry data of tumor should consider microenvironmental factors
  3. Interpretation of immunohistochemistry data of tumor should consider microenvironmental factors
  4. EphB4 is overexpressed in gliomas and promotes the growth of glioma cells
  5. Combination of platelet count and mean platelet volume (COP-MPV) predicts postoperative prognosis in both resectable early and advanced stage esophageal squamous cell cancer patients
  6. Pathological and prognostic significance of hypoxia-inducible factor 1α expression in epithelial ovarian cancer: a meta-analysis
  7. Complete loss of STAG2 expression is an indicator of good prognosis in patients with bladder cancer
  8. MicroRNA-486-5p targeting PIM-1 suppresses cell proliferation in breast cancer cells
  9. Aberrant regulation of miR-15b in human malignant tumors and its effects on the hallmarks of cancer
  10. Glutathione S-transferase P1 Ile105Val polymorphism contributes to increased risk of gastric cancer in East Asians
  11. Association of peripheral CD4+ CXCR5+ T cells with chronic lymphocytic leukemia
  12. miR-448 suppressed gastric cancer proliferation and invasion by regulating ADAM10
  13. Crosstalk between TGF-β signaling and miRNAs in breast cancer metastasis
  14. Crosstalk between TGF-β signaling and miRNAs in breast cancer metastasis
  15. Prevalence of RET/PTC1 and RET/PTC3 gene rearrangements in Chennai population and its correlation with clinical parameters
  16. Relationships of FOXE1 and ATM genetic polymorphisms with papillary thyroid carcinoma risk: a meta-analysis
  17. IL-17 gene polymorphism is associated with susceptibility to gastric cancer
  18. Increased expression of FOXQ1 is a prognostic marker for patients with gastric cancer
  19. SPAG9 is overexpressed in human astrocytoma and promotes cell proliferation and invasion
  20. Hexokinase 2 overexpression promotes the proliferation and survival of laryngeal squamous cell carcinoma
  21. Risk of gastrointestinal perforation in cancer patients treated with aflibercept: a systematic review and meta-analysis
  22. Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potential therapeutic target
  23. PGE 2 signaling and its biosynthesis-related enzymes in cholangiocarcinoma progression
  24. Breast cancer risk in relation to TP53 codon 72 and CDH1 gene polymorphisms in the Bangladeshi women
  25. Association between x-ray repair cross-complementing group 3 ( XRCC3 ) genetic polymorphisms and papillary thyroid cancer susceptibility in a Chinese Han population
  26. Inhibition of topoisomerase IIα sensitizes FaDu cells to ionizing radiation by diminishing DNA repair
  27. Interleukin-6 receptor in spindle-shaped stromal cells, a prognostic determinant of early breast cancer
  28. Endoglin (CD105) expression in ovarian serous carcinoma effusions is related to chemotherapy status
  29. HCC-DETECT: a combination of nuclear, cytoplasmic, and oncofetal proteins as biomarkers for hepatocellular carcinoma
  30. MicroRNA218 inhibits glioma migration and invasion via inhibiting glioma-associated oncogene homolog 1 expression at N terminus
  31. Prognostic significance of Bcl-2 expression in non-basal triple-negative breast cancer patients treated with anthracycline-based chemotherapy
  32. Overexpression of ADAMTS5 can regulate the migration and invasion of non-small cell lung cancer
  33. Current evidences on IL1B polymorphisms and lung cancer susceptibility: a meta-analysis
  34. Alterations of circulating follicular helper T cells and interleukin 21 in diffuse large B-cell lymphoma
  35. Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype
  36. Investigation of circulating antibodies to ANXA1 in breast cancer
  37. Critical role of miR-155/FoxO1/ROS axis in the regulation of non-small cell lung carcinomas
  38. Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population
  39. Effect of expressions of tumor necrosis factor α and interleukin 1B on peritoneal metastasis of gastric cancer
  40. Retraction Note to: Diagnostic investigations of canine prostatitis incidence together with benign prostate hyperplasia, prostate malignancies, and biochemical recurrence in high-risk prostate cancer as a model for human study
  41. XRCC1 Arg399Gln polymorphism is not associated with oral cancer risk: evidence from a meta-analysis
  42. The association between the APE1 Asp148Glu polymorphism and breast cancer susceptibility: a meta-analysis based on case–control studies
  43. Clinical significance and biological roles of CARMA3 in human bladder carcinoma
  44. RETRACTED ARTICLE: XRCC3 T241M polymorphism is associated risk of hepatocellular carcinoma in the Chinese
  45. BRCA1 promoter hypermethylation and protein expression in ovarian carcinoma—an Indian study
  46. RETRACTED ARTICLE: miR-203 suppression in gastric carcinoma promotes Slug-mediated cancer metastasis
  47. TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCα and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620
  48. Hepatoma-derived growth factor: a novel prognostic biomarker in intrahepatic cholangiocarcinoma
  49. Kallikrein-related peptidase-6 ( KLK6 ) mRNA expression is an independent prognostic tissue biomarker of poor disease-free and overall survival in colorectal adenocarcinoma
  50. SMAD7 rs12953717 polymorphism contributes to increased risk of colorectal cancer
  51. Inhibitor of growth-4 is a potential target for cancer therapy
  52. Expression and biological role of cytoglobin in human ovarian cancer
  53. The combination of a nuclear HMGB1-positive and HMGB2-negative expression is potentially associated with a shortened survival in patients with pancreatic ductal adenocarcinoma
  54. Epstein–Barr virus latent antigens EBNA3C and EBNA1 modulate epithelial to mesenchymal transition of cancer cells associated with tumor metastasis
  55. Propofol induces endoplasmic reticulum (ER) stress and apoptosis in lung cancer cell H460
  56. The predictive value of alkaline phosphatase and lactate dehydrogenase for overall survival in patients with esophageal squamous cell carcinoma
  57. Reanalysis of microRNA expression profiles identifies novel biomarkers for hepatocellular carcinoma prognosis
  58. Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma
  59. T-box transcription factor Brachyury in lung cancer cells inhibits macrophage infiltration by suppressing CCL2 and CCL4 chemokines
  60. Colorectal cancer: a researcher’s perspective of the molecular angel’s gone eccentric in the Vale of Kashmir
  61. Differential expression of inflammasomes in lung cancer cell lines and tissues
  62. MiRNA-221-3p desensitizes pancreatic cancer cells to 5-fluorouracil by targeting RB1
  63. Serum soluble MICB (sMICB) correlates with disease progression and survival in melanoma patients
  64. Proto-oncogene Wip1, a member of a new family of proliferative genes in NSCLC and its clinical significance
  65. Association of CTLA4 gene polymorphism (rs5742909) with cervical cancer: a meta-analysis
  66. Clinical impact of circulating microRNAs as blood-based marker in childhood acute lymphoblastic leukemia
  67. Decreased expression of p27 is associated with malignant transformation and extrathyroidal extension in papillary thyroid carcinoma
  68. Exosomes mediate drug resistance transfer in MCF-7 breast cancer cells and a probable mechanism is delivery of P-glycoprotein
  69. Exosomes mediate drug resistance transfer in MCF-7 breast cancer cells and a probable mechanism is delivery of P-glycoprotein
  70. Prognosis of invasive breast cancer after adjuvant therapy evaluated with VEGF microvessel density and microvascular imaging
  71. N-acetyltransferase 2 genetic variants confer the susceptibility to head and neck carcinoma: evidence from 23 case–control studies
  72. Aberrant TIG1 methylation associated with its decreased expression and clinicopathological significance in hepatocellular carcinoma
  73. Associations between polymorphisms of the XPC gene and lung cancer susceptibility: a meta-analysis
  74. CARMA3 overexpression accelerates cell proliferation and inhibits paclitaxel-induced apoptosis through NF-κB regulation in breast cancer cells
  75. Glycolytic activity with 18 F-FDG PET/CT predicts final neoadjuvant chemotherapy response in breast cancer
  76. Regulation of autophagy by Ca 2+
  77. Differential gene expression of Wnt signaling pathway in benign, premalignant, and malignant human breast epithelial cells
  78. Mitochondrial D310 instability in Asian Indian breast cancer patients
  79. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines
  80. Radical surgery may be not an optimal treatment approach for pulmonary MALT lymphoma
  81. MiR-511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3
  82. Downregulation of long noncoding RNA NONHSAT037832 in papillary thyroid carcinoma and its clinical significance
  83. Extracellular cytochrome c as a biomarker for monitoring therapeutic efficacy and prognosis of non-small cell lung cancer patients
  84. Runx2, a target gene for activating transcription factor-3 in human breast cancer cells
  85. Evaluation of squamous cell carcinoma antigen-immunoglobulin M complex (SCCA-IGM) and alpha- l -fucosidase (AFU) as novel diagnostic biomarkers for hepatocellular carcinoma
  86. HtrA3 is negatively correlated with lymph node metastasis in invasive ductal breast cancer
  87. Association of cancer stem cell markers genetic variants with gallbladder cancer susceptibility, prognosis, and survival
  88. The dual regulatory role of miR-204 in cancer
  89. Bufalin exerts antitumor effects by inducing cell cycle arrest and triggering apoptosis in pancreatic cancer cells
  90. Investigation of microRNA-155 as a serum diagnostic and prognostic biomarker for colorectal cancer
  91. Prognostic significance of GPC5 expression in patients with prostate cancer
  92. An updated meta-analysis of transforming growth factor-β1 gene: three polymorphisms with gastric cancer
  93. RETRACTED ARTICLE: Comprehensive assessment of the association of ERCC2 Lys751Gln polymorphism with susceptibility to cutaneous melanoma
  94. Bypassing the need for pre-sensitization of cancer cells for anticancer TRAIL therapy with secretion of novel cell penetrable form of Smac from hA-MSCs as cellular delivery vehicle
  95. RETRACTED ARTICLE: Nrdp1 inhibits metastasis of colorectal cancer cells by EGFR signaling-dependent MMP7 modulation
  96. Predictive value of immunogenic cell death biomarkers HMGB1, sRAGE, and DNase in liver cancer patients receiving transarterial chemoembolization therapy
  97. Influence of different hypoxia models on metastatic potential of SGC-7901 gastric cancer cells
  98. Distribution of mast cells in benign odontogenic tumors
  99. Genetic association between p53 codon 72 polymorphism and risk of cutaneous squamous cell carcinoma
  100. Mammary renin–angiotensin system-regulating aminopeptidase activities are modified in rats with breast cancer
  101. FokI polymorphism in vitamin D receptor gene and risk of breast cancer among Caucasian women
  102. The Arg399Gln polymorphism in the XRCC1 gene is associated with increased risk of hematological malignancies
  103. The expression of metabolism-related proteins in phyllodes tumors
  104. Pseudogene-expressed RNAs: a new frontier in cancers
  105. The subsets of dendritic cells and memory T cells correspond to indoleamine 2,3-dioxygenase in stomach tumor microenvironment
  106. Erythropoietin-stimulating agents and clinical outcomes in metastatic breast cancer patients with chemotherapy-induced anemia: a closed debate?
  107. Pyruvate dehydrogenase B promoted the growth and migration of the nasopharyngeal carcinoma cells
  108. The expression of annexin II and Lewis y antigen in ovarian epithelial tumors and the correlation between them
  109. Prognostic significance of Ku80 in pT2N0M0 esophageal squamous cell carcinoma after Ivor-Lewis esophagectomy
  110. Galectin-8 is associated with recurrence and survival of patients with non-metastatic gastric cancer after surgery
  111. XRCC1 R399Q polymorphism and colorectal cancer risk in the Chinese Han population: a meta-analysis
  112. Diagnostic value of CD117 in differential diagnosis of acute leukemias
  113. ALDH1A1 mediates resistance of diffuse large B cell lymphoma to the CHOP regimen
  114. Prognostic significance of Ku80 in pT2N0M0 esophageal squamous cell carcinoma after Ivor-Lewis esophagectomy
  115. Quantitative assessment of the association between glutathione S-transferase P1 Ile105Val polymorphism and bladder cancer risk
  116. CIZ1 is upregulated in hepatocellular carcinoma and promotes the growth and migration of the cancer cells
  117. Missing link between microRNA and prostate cancer
  118. RETRACTED ARTICLE: Potent antitumor activity of HSP90 inhibitor AUY922 in adrenocortical carcinoma
Search Result: