Authors: Changwen Zhang Zhifei Liu Li Wang Baomin Qiao E Du Li Li Yong Xu Zhihong Zhang
Publish Date: 2015/12/02
Volume: 37, Issue: 5, Pages: 6413-6418
Abstract
The objective of this study was to evaluate the protein level of glypican5 GPC5 and its relationship with clinicopathologic significance in prostate cancer The protein level of GPC5 in 160 prostate cancer tissues and 60 adjacent normal samples was examined by immunohistochemistry analysis and the results were correlated with clinicopathologic parameters The level of GPC5 in prostate cancer tissues was markedly lower than that in normal cases especially in highrisk prostate cancer Additionally the low expression of GPC5 was closely associated with increased serum prostatespecific antigen PSA higher Gleason scores advanced tumor stage T3 positive lymph node metastasis and biochemical recurrence Moreover GPC5 low expression was an independent prognostic factor for overall survival of patients with prostate cancer GPC5 protein expression showed a close correlation with the tumorigenesis and tumor progression of prostate cancer and that might be applied as a novel biomarker for the prediction of diagnosis and prognosis of prostate cancerThis work was supported by grants from the National Natural Science Foundation of China grant numbers 81402124 81472416 and 21577097 the Chinese Academy of Science and Technology of Strategic Leading Science and Technology B grant numbers XDB14040401 and XDB14010300 the Application Base and Frontier Technology Project of Tianjin grant number 14JCQNJC10800 the Tianjin City High School Science Technology Fund Planning Project grant number 20130124 and the Science and Technology Fund of Tianjin Municipal Bureau of Health grant numbers 2014KZ110 and 2015KZ109 We thank the lab members for the great assistance with the experiments and reagentsZhihong Zhang and Yong Xu contributed to the conception and design of the study Changwen Zhang Li Wang and Baomin Qiao contributed to the development of methodology Changwen Zhang E Du and Li Li contributed to the acquisition of data acquired and managed patients provided facilities etc Changwen Zhang Zhifei Liu and Zhihong Zhang contributed to the analysis and interpretation of data eg statistical analysis biostatistics computational analysis Changwen Zhang Zhihong Zhang and Yong Xu contributed to the writing review and/or revision of the manuscript Changwen Zhang and Zhifei Liu contributed to the administrative technical or material support ie reporting or organizing data constructing databases Zhihong Zhang and Yong Xu contributed to the study supervision
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