Authors: Xuefei Shi Fengqi Nie Zhaoxia Wang Ming Sun
Publish Date: 2015/12/10
Volume: 37, Issue: 2, Pages: 1471-1478
Abstract
Over the past decade the importance of nonproteincoding functional elements in the human genome has emerged from the water and been identified as a key revelation in postgenomic biology Since the completion of the ENCODE Encyclopedia of DNA Elements and FANTOM Functional Annotation of Mammals project tens of thousands of pseudogenes as well as numerous long noncoding RNA lncRNA genes were identified However while pseudogenes were initially regarded as nonfunctional relics littering the human genome during evolution recent studies have revealed that they play critical roles at multiple levels in diverse physiological and pathological processes especially in cancer through parentalgenedependent or parentalgeneindependent regulation Herein we review the current knowledge of pseudogenes and synthesize the nascent evidence for functional properties and regulatory modalities exerted by pseudogenetranscribed RNAs in human cancers and prospect the potential as molecular signatures in cancer reclassification and tailored therapyThis work was supported by grants from the National Natural Science Foundation of China No81472198 the Key Clinical Medicine Technology Foundation of Jiangsu Province NoBL2014096 and the Medical Key Talented Person Foundation of the Jiangsu Provincial Developing Health Project NoRC2011080
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