Authors: ChangJiang Qin KaiWu Xu ZhiHui Chen ErTao Zhai YuLong He XinMing Song
Publish Date: 2015/01/13
Volume: 36, Issue: 2, Pages: 461-466
Abstract
Xray repair crosscomplementing group 1 XRCC1 plays a key role in DNA repair genetic instability and tumorigenesis The XRCC1 R399Q polymorphism has been reported in some studies to influence the risk of colorectal cancer CRC though this remains controversial We performed a metaanalysis to determine the association of XRCC1 R399Q polymorphisms with CRC risk in the Chinese Han population A literature search was conducted using PubMed EMBASE and the China National Knowledge Infrastructure to identify eligible studies published before June 2014 The pooled odds ratio OR and corresponding 95 confidence interval CI were used to estimate the effect of XRCC1 R399Q polymorphisms on CRC risk Eleven case–control studies with a total of 3194 CRC cases and 4472 controls were identified No significant association between the XRCC1 R399Q polymorphism and CRC risk was observed in the Chinese Han population Gln/Gln vs Arg/Arg OR = 126 95 CI = 085–187 P OR = 0242 Arg/Gln vs Arg/Arg OR = 095 95 CI = 070–118 P OR = 0651 dominant model OR = 109 95 CI = 086–138 P OR = 0480 and recessive model OR = 124 95 CI = 091–170 P OR = 0177 After excluding two studies that deviated from the Hardy–Weinberg equilibrium there remained no significant association between XRCC1 R399Q and CRC risk No publication bias was found using the funnel plot and Egger’s test Our metaanalysis results suggest that the XRCC1 R399Q polymorphism is not associated with increased risk of CRC in the Chinese Han population
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