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Title of Journal: Tumor Biol

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Abbravation: Tumor Biology

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Springer Netherlands

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DOI

10.1016/0041-0101(76)90106-9

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1423-0380

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Aberrant regulation of miR15b in human malignant

Authors: Ci Zhao Guanyu Wang Yuanyuan Zhu Xiaobo Li Feihu Yan Chunhui Zhang Xiaoyi Huang Yanqiao Zhang
Publish Date: 2015/11/19
Volume: 37, Issue: 1, Pages: 177-183
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Abstract

MicroRNAs encoded by the miR15b/162 cluster act as tumor suppressors Aberrant regulation of miR15b in human malignant tumors is reportedly involved in cancer development contributing to cell death reduced proliferation angiogenesis and metastasis resistance metabolism reprogramming genome instability and tumorassociated inflammation In this review we summarize the mechanisms involved in regulating miR15b expression in mammalian tumors and discuss the effects of miR15b dysregulation on the hallmarks of cancer and highlight its role as a potentially valuable target for future cancer therapeutic strategiesThis work is supported by the National Natural Science Foundation of China No 81172265 Supporting Certificated of Heilongjiang Postdoctoral Scientific Research Developmental Fund No LBHQ14108 and Start Funding of The Affiliated Tumour Hospital of Harbin Medical University NoYRC201401

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