Authors: Balraj Singh Gill Jimi Marin Alex Navgeet Sanjeev Kumar
Publish Date: 2016/01/28
Volume: 37, Issue: 5, Pages: 5683-5704
Abstract
MicroRNAs are the noncoding RNAs which regulate endogenous gene expression in animal and plant cells Alterations in the level of microribonucleic acids miRNAs involving the deletions overexpression mutations epigenetic silencing or dysregulation of transcription factors that target specific miRNAs may culminate in various diseases including cancer Recent findings demonstrate the role of miRNAs in prostate cancer Numerous discoveries of miRNAs have marked the research and development surrounding prostate cancer management diagnosis and therapy which has made prediction easy but the effective treatment strategy remains a mystery This review seeks to draw a link between miRNA and prostate cancer through an understanding of the numerous signaling pathways that these miRNAs control which may prove to be helpful in identifying therapeutically interesting molecular targets
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