Authors: Abbas Ahmadi AliAkbar Poorfathollah Mahnaz Aghaiipour Mansour Rezaei Mahin Nikooghoftar Mohammad Abdi Alireza Gharib Amir Amini
Publish Date: 2014/04/11
Volume: 35, Issue: 7, Pages: 6763-6768
Abstract
Ckit receptor CD117 and its ligand stem cell factor play a key role in normal hematopoiesis It has been demonstrated that its expression extremely increases in leukemias with myeloid commitment We analyzed findings on CD117 expression together with other myeloid related markers in 203 de novo acute leukemias referred to Iranian immunophenotyping centers Iranian Blood Transfusion Organization IBTO and Baghiatallah Hospital BH All cases were characterized based on the French American British cooperative group FAB and European Group for Immunological Classification of Leukemias EGIL The cases comprised of 111 acute myeloblastic leukemia AML 86 acute lymphoblastic leukemia ALL and 6 acute undifferentiated leukemia AUL CD117 was positive in 75 of AML and 50 of AUL whereas none of the ALL cases was positive for this marker Although CD117 was positive in 100 of M5a cases no M5b positive was found p = 0036 The calculated specificity for myeloid involvement was 100 for CD117 and CD33 and 98 for CD13 and CD15 p 0001 The calculated sensitivity for myeloid involvement was 83 76 64 and 41 for CD13 CD117 CD33 and CD15 respectively p 0001 We concluded that CD117 expression is a specific and rather sensitive marker for differential diagnosis between AML and ALL and except for M5 subtypes it fails to determine FAB subtypes lack of expression in M5 can identify M5b Therefore it should be included in the routine primary panel for diagnosis of acute leukemias
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