Authors: MeiLing Zhu RuiXi Hua Leizhen Zheng
Publish Date: 2013/12/28
Volume: 35, Issue: 4, Pages: 2931-2939
Abstract
Xeroderma pigmentosum complementation group C XPC gene plays a critical role in DNA damage recognition and its functional single nucleotide polymorphisms SNPs may alter DNA repair capacity and cancer susceptibility Numerous epidemiological studies have investigated the associations between XPC Lys939Gln and Ala499Val polymorphisms and lung cancer susceptibility but the conclusions are inconclusive We searched three electronic databases MEDLINE EMBASE and EBSCO for eligible publications and performed a metaanalysis assessing the associations between XPC Lys939Gln and Ala499Val polymorphisms and lung cancer risk We also analysed the genotypemRNA expression correlation using the data of HapMap phase II release 23 with 270 individuals from 4 ethnicities for exploring biological plausibility of our findings We included ten published studies of 3882 cases and 5219 controls for Lys939Gln and five studies with 2605 cases and 3329 controls for Ala499Val When all studies were pooled we found a significantly increased overall lung cancer risk for Lys939Gln polymorphism recessive model OR = 114 95 CI = 101–129 P = 0218 for heterogeneity Stratification analysis also showed a higher lung cancer risk in Asian populations recessive model OR = 126 95 CI = 104–152 P = 0263 for heterogeneity Interestingly we found significant correlation between Lys939Gln genotypes and XPC mRNA expression for Asian populations as well However we did not observe any association between Ala499Val polymorphism and overall lung cancer risk nor in further stratification analysis This metaanalysis suggests that XPC Lys939Gln polymorphism may contribute to lung cancer risk which needs further validation in single larger studies
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