Authors: Menha Swellam Nashwa ElKhazragy
Publish Date: 2016/02/09
Volume: 37, Issue: 8, Pages: 10571-10576
Abstract
Aberrant microRNA miRNA expression participates in childhood acute lymphoblastic leukemia ALL This study aimed to investigate the expression of miRNA100 miRNA196a and miRNA146a among childhood ALL and study their correlation with other hematological parameters and different phenotypes Peripheral blood mononuclear cells PMNCs were obtained from 85 childhood ALL and 25 healthy children for the detection of miRNA expression using quantitative realtime PCR Significant higher median levels were reported for ALL compared to control children The diagnostic efficacy for miRNA146a was superior as both sensitivity and specificity were absolute A significant correlation was observed between higher expression of miRNA100 and lower platelet and lymphocyte counts high expression of miRNA146a showed significant correlation with low total leukocyte count TLC and lymphocyte counts Significant relation was reported between studied miRNAs and different phenotyping miRNA100 miRNA196a and miRNA146a have significant role in childhood ALL leukemogenesis and they may be useful as biological diagnostic molecular markers
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