Authors: Liang Zhang Zhaolan Xiang Rui Hao Ru Li Yi Zhu
Publish Date: 2013/12/13
Volume: 35, Issue: 4, Pages: 3585-3595
Abstract
Previous evidence indicated that Nacetyltransferase 2 NAT2 polymorphisms might be a risk factor for several cancers A number of studies have been conducted on the association between NAT2 polymorphisms and head and neck cancer HNC risk Nevertheless the results were conflicting Published metaanalysis on this issue has generated inconclusive results Thus we aimed to derive a more precise estimation of the relationship by conducting an updated metaanalysis Published data prior to August 2013 have been searched and screened Subgroup analysis on ethnicity source of controls sample size and genotyping method were also performed As a result a total of 23 case–control studies including 4028 cases and 4872 controls were selected for analysis Interestingly the results showed that NAT2 polymorphisms might increase HNC risk for the overall data OR 123 95 CI 101–149 Moreover in subgroup analyses according to ethnicity data showed that slow acetylators might increase HNC susceptibility among Asians OR 178 95 CI 127–249 but not among Caucasians or mixed ethnicities In conclusion NAT2 polymorphism might be a lowpenetrant risk factor for HNC among Asians
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