Authors: Chenguang Li Changli Wang
Publish Date: 2013/06/20
Volume: 34, Issue: 6, Pages: 3477-3482
Abstract
Interleukin 1 beta IL1B plays a key role in mediating acute and chronic inflammation which is further correlated with lung carcinogenesis Several polymorphisms on IL1B gene have been identified and a series of epidemiological studies have examined the association between IL1B polymorphisms and lung cancer risk However these findings are inconclusive To derive a precise estimation of the relationship a metaanalysis was performed We summarized 12 eligible publications on three commonly studied IL1B polymorphisms ie −31 T/C −511 T/C and +3954 C/T by searching electronic databases Combined odds ratio OR with 95 confidence interval CI was calculated to assess the strength of association between them Heterogeneity and publication bias were also assessed We observed a significant association between IL1B polymorphisms and lung cancer For −31T/C the overall OR 95 CI of TT/TC versus CC was 123 106–143 For +3954 C/T the overall OR 95 CI of CC versus TT and CC versus CT/TT were 092 086–099 and 092 086–099 respectively In conclusion this metaanalysis suggests that the IL1B −31 T/C and +3954 C/T polymorphisms are associated with lung cancer risk However larger number of samples and studies with homogeneous lung cancer patients are needed to confirm these findings
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