Authors: LiQiang Zhi Wei Ma Hong Zhang SiXiang Zeng Bo Chen
Publish Date: 2013/11/28
Volume: 35, Issue: 4, Pages: 3255-3259
Abstract
Despite the knowledge on many genetic variants present in osteosarcoma the complexity of this disease precludes placing its biology into a simple conceptual framework RECQL is a DNA helicase involved in DNA mismatch repair and has been reported to be associated with many human cancers We aimed to investigate the association of RECQL genetic polymorphism with osteosarcoma in a Chinese population We selected three polymorphisms of the RECQL5 gene rs820196 rs820200 and rs4789223 in the present study TaqMan method was utilized for genotyping these three SNPs in 212 patients with osteosarcoma and 240 age and sexmatched noncancer controls In our study we found that CC genotype in rs820196 175 vs 83 P = 0005 and AA genotype in rs4789223 217 vs 142 P 0001 were more frequent in osteosarcoma group compared to the control group respectively We also found that the C allele of rs820196 OR = 1492 95 CI 1138∼1951 P = 0004 and A allele of rs4789223 OR = 1767 95 CI 1354 ∼ 2301 P 0001 were common in the osteosarcoma patients than those in the control subjects respectively Haplotype analysis showed that TTA OR = 3469 95 CI 1798∼6695 P 0001 was associated with increased risk for osteosarcoma However the TTG OR = 0578 95 CI 0442∼0756 was associated with decreased risk for osteosarcoma Our results suggested that RECQL5 genetic polymorphisms were associated with osteosarcoma in a Chinese population
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