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Title of Journal: Tumor Biol

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Abbravation: Tumor Biology

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Springer Netherlands

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DOI

10.1007/s002650000308

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ISSN

1423-0380

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MiRNA2213p desensitizes pancreatic cancer cells

Authors: Lijun Zhao Dongling Zou Xueju Wei Lanlan Wang Yuanyuan Zhang Siqi Liu Yanmin Si Hualu Zhao Fang Wang Jia Yu Yanni Ma Guotao Sun
Publish Date: 2016/10/10
Volume: 37, Issue: 12, Pages: 16053-16063
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Abstract

Pancreatic cancer is a highly lethal disease due to its rapid dissemination and resistance to conventional chemotherapy MicroRNAs miRNAs are emerging as novel regulators of chemoresistance which modulate the expression of drug resistancerelated genes MiRNA221 has been reported to be associated with chemoresistance in various types of cancer But the detailed molecular mechanism about miR2213p regulating 5fluorouracil 5FU resistance in human pancreatic cancer remains to be clarified In this study we investigated the association between miR2213p expression and 5FU sensitivity Studies on pancreatic cancer cell lines suggested an increased 5FU resistance with miR2213p overexpression In addition the results indicated that miR2213p downregulated RB1 expression by directly binding to its 3′UTR and therefore caused increased several aspects of pancreatic cancer pathogenesis including proliferation migration invasion and epithelialmesenchymal transition EMT Collectively our findings revealed the important role of miR2213p in promoting 5FU resistance of pancreatic cancer cells and provided a potential therapeutic target for pancreatic cancer

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