Authors: Liang Wang Zhongjun Xia Yujing Zhang Huiqiang Huang Tongyu Lin Yue Lu
Publish Date: 2015/03/24
Volume: 36, Issue: 8, Pages: 6409-6416
Abstract
Primary pulmonary MALT lymphoma is a rare disease and no standard treatments have been defined yet In this study 38 consecutive patients from single center were reviewed Among 25 patients with localized disease radical surgery were performed in 12 patients and the other 13 patients had chemotherapy combined with 7 patients or without 6 patients radiotherapy No significant difference in overall survival OS was found between patients who received surgery or not however patients treated with chemotherapy had superior progressionfree survival PFS than those treated with upfront surgery P = 0032 Among the 12 patients who received radical surgery 7 were given adjuvant chemotherapy and 1 patient had consolidation radiotherapy No significant differences in PFS and OS exist between those who received adjuvant treatment or not P 005 For patients who received chemotherapy PFS and OS were significantly better for those treated with cyclophosphamidebased therapy than fludarabinebased therapy At a median followup time of 611 months 5 and 10year PFS rate was 700 and 430 respectively and 5 and 10year OS rate was both 810 In conclusion we confirmed the indolent behavior and favorable outcome of this disease In order to preserve lung function and reduce the risks associated with surgery radiotherapy or rituximab in combination with alkylating drugbased chemotherapy should be considered as firstline option for pulmonary MALT lymphomaWe thank all physicians at Sun Yatsen University Cancer Center for allowing us to include their patients We also appreciate the cooperation of all pathologists at Sun Yatsen University Cancer Center for their support This work received grant support from the National Natural Science Foundation of China contract/grant number 81400159 the Medical Research Foundation of Guangdong Province grant number B2014158 the Young Teachers’ Cultivation Project of Sun Yatsen University No 12ykpy54 and the Outstanding Young Talents Project of Sun Yatsen University Cancer Center No 04190101
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