Authors: Xuesong Wu Haoran Tang Guobin Liu Hui Wang Jie Shu Feng Sun
Publish Date: 2016/02/08
Volume: 37, Issue: 8, Pages: 10545-10551
Abstract
MicroRNAs miRNAs are a class of short noncoding RNAs that act a crucial role in tumor development Previous studies showed that miR448 expression was deregulated in many tumors However the role of miR448 in gastric cancer GC remains unknown In our study we demonstrated that miR448 expression was downregulated in GC tissues compared with the corresponding nontumor tissues We also showed that miR448 expression was downregulated in GC cell lines Ectopic expression of miR448 suppressed GC cell proliferation colony formation and invasion Moreover we identified A Disintegrin And Metalloproteinases 10 ADAM10 as a direct target gene of miR448 in GC cell ADAM10 expression was upregulated in GC tissues and cells Furthermore the expression level of miR448 was negatively correlated with the expression level of ADAM10 in GC tissues Moreover ADAM10 overexpression rescued the effect of miR448mediated GC cell proliferation colony formation and invasion These results demonstrated that miR448 might play as a tumor suppressor miRNA partly through targeting ADAM10 expression
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