Authors: Zhenlong Wang Li Xue Tie Chong Hecheng Li Haiwen Chen Ziming Wang
Publish Date: 2013/03/13
Volume: 34, Issue: 3, Pages: 1651-1657
Abstract
Previous studies investigating the association between glutathione Stransferase P1 GSTP1 Ile105Val polymorphism and bladder cancer risk reported controversial results This study aimed to quantify the strength of the association between GSTP1 Ile105Val polymorphism and bladder cancer risk by performing a metaanalysis We searched the PubMed Embase and Wanfang databases for publications on the association between GSTP1 Ile105Val polymorphism and bladder cancer risk We estimated the pooled odds ratios ORs with their confidence intervals 95 CIs to assess the association Twentyfive individual studies with a total of 12360 subjects were finally included Metaanalysis of all 25 studies showed that GSTP1 Ile105Val polymorphism was associated with increased risk of bladder cancer risk under four genetic comparison models for G versus A randomeffect OR = 119 95 CI 105–135 for GG versus AA randomeffect OR = 149 95 CI 112–197 for GG/GA versus AA randomeffect OR = 120 95 CI 103–139 for GG versus GA/AA randomeffect OR = 141 95 CI 110–180 Sensitivity analysis showed that GSTP1 Ile105Val polymorphism was still associated with bladder cancer risk under three genetic comparison models for G versus A randomeffects OR = 113 95 CI 101–126 for GG versus AA randomeffects OR = 129 95 CI 101–165 for GG versus GA/AA randomeffects OR = 119 95 CI 104–135 No evidence of publication bias was observed This metaanalysis shows that there is an obvious association between GSTP1 Ile105ValIle105Val polymorphism and bladder cancer risk and GSTP1 ILE105VAL polymorphism contributes to bladder cancer risk
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