Authors: Tingting Zhao Zhifeng Miao Zhenning Wang Yingying Xu Jianhua Wu Xingyu Liu Yi You Jiguang Li
Publish Date: 2013/05/25
Volume: 34, Issue: 5, Pages: 3041-3047
Abstract
CARMA3 was recently reported to be overexpressed in several cancers and associated with malignant behavior of cancer cells However the expression pattern and biological roles of CARMA3 in breast cancer have not been reported In the present study we found that CARMA3 was overexpressed in 419 of breast cancer specimens Significant association was observed between CARMA3 overexpression and TNM stage p = 00223 tumor size p = 00227 and ErbB2 status p = 00049 Furthermore knockdown of CARMA3 expression in MDAMB435 cells with high endogenous expression decreased cell proliferation and sensitized cell to paclitaxelinduced apoptosis while overexpression of CARMA3 in MDAMB231 cell line promoted cell proliferation and inhibited apoptosis Further analysis showed that CARMA3 depletion downregulated and its overexpression upregulated cyclin D1 Bcl2 and pIκB levels In conclusion our study demonstrated that CARMA3 is overexpressed in breast cancers CARMA3 facilitates proliferation and inhibits apoptosis through nuclear factorkappaB signaling
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