Authors: Liang Du Yuqi Liu Pei Xue Chenxi Song Jiani Shen Qing He Yuanling Peng Xiang Tong Lizhi Tang Yonggang Zhang
Publish Date: 2015/01/27
Volume: 36, Issue: 6, Pages: 4545-4554
Abstract
The associations between the Arg399Gln polymorphism in Xray repair crosscomplementing gene 1 XRCC1 gene and the risk of hematological malignancies have been extensively investigated However the results were inconsistent The objective of the current study is to investigate the association by metaanalysis We searched PubMed database Embase database CNKI database Wanfang database and Weipu database covering all studies until August 7 2013 Statistical analysis was performed by using the Revman42 software and the Stata100 software A total of 27 case–control studies concerning the Arg399Gln polymorphism were included from 26 articles The results suggested that the Arg399Gln polymorphism was not associated with an increased/decreased risk of hematological malignancies in total analysis OR = 115 95 confidence interval CI = 097–135 P = 010 for Arg/Gln + Gln/Gln vs Arg/Arg In the subgroup analysis by ethnicity and cancer types significant association was found in Asians OR = 135 95 CI = 104–175 P = 003 but not in Europeans OR = 107 95 CI = 086–133 P = 056 and in leukemia OR = 125 95 CI = 102–154 P = 003 but not in lymphoma OR = 098 95 CI = 080–120 P = 084 or myeloma OR = 113 95 CI = 023–569 P = 088 The current metaanalysis indicated that the Arg399Gln polymorphism in the XRCC1 gene might be a risk factor for hematological malignancies in Asians or for leukemia In future more largescale case–control studies are needed to validate these results
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