Authors: HongBing Xu Huan Yang Tingting Liu Hong Chen
Publish Date: 2013/10/11
Volume: 35, Issue: 2, Pages: 1605-1608
Abstract
Previous studies suggested that CTLA4 polymorphism rs5742909 is associated with susceptibility to cervical cancer In the present study we performed a metaanalysis to systematically summarize the possible association between rs5742909 and the risk for cervical cancer We conducted a search of case–control studies on the associations of rs5742909 with susceptibility to cervical cancer in PubMed EMBASE ISI Web of Science Cochrane Central Register of Controlled Trials Wanfang database in China and Chinese National Knowledge Infrastructure databases We extracted the data from eligible studies for metaanalysis The association of cervical cancer risk with rs5742909 was estimated by pooled odds ratios ORs and 95 confidence intervals 95 CIs There were four studies on rs5742909 and cervical cancer in our metaanalysis Our results suggested that both T allele frequency OR = 163 95 CI 106–250 P = 003 and TT + CT genotype distribution OR = 172 95 CI 107–277 P = 003 of the rs5742909 were associated with risk for cervical cancer This metaanalysis suggests that rs5742909 is associated with the risk of cervical cancer Welldesigned studies with larger sample size and more ethnic groups are required to further validate the results
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