Authors: Zhiyong Zhao Chuan Liu Yong Zeng Lei Gu Mingzhen Ying Ning Wang Bin Hao Huiyan Yao Changqing Su Yajie Wang Yuchen Ma
Publish Date: 2014/01/14
Volume: 35, Issue: 5, Pages: 4727-4734
Abstract
Published data regarding the association between the APE1 Asp148Glu polymorphism and breast cancer susceptibility showed inconclusive results This metaanalysis of literatures was performed to draw a more precise estimation of the relationship We systematically searched PubMed Embase Elsevier and Springer for relevant articles published before December 10 2013 The strength of association between APE1 Asp148Glu polymorphism and breast cancer susceptibility was assessed by odds ratio OR with the corresponding 95 confidence interval 95 CI using the software Stata version 100 A total of 7 case–control studies including 3460 cases and 3909 controls were included for analysis Overall no significant associations were found between the APE1 Asp148Glu polymorphism and breast cancer susceptibility for GG vs TT OR = 100 95 CI = 087–114 TG vs TT OR = 106 95 CI = 095–118 the dominant model GG + TG vs TT OR = 104 95 CI = 094–116 and the recessive model GG vs TG + TT OR = 099 95 CI = 088–111 In subgroup analysis a significant association was found for TG vs TT in Asian subgroup OR = 117 95 CI = 100 ~ 136 and in populationbased subgroup OR = 118 95 CI = 100 ~ 138 This metaanalysis suggested that the APE1 Asp148Glu polymorphism was a risk factor for breast cancer susceptibility among Asian populationThis study was supported by Natural Science Foundation of The People’s Republic of China no 81072175 81102010 81202096 81372854 Shanghai Science and Technology Committee no 114119a7500 no 06DZ19505 and no13NM1401504 and Changhai hospital 1255 discipline construction projects No CH125530400 The funders had no role in study design data collection and analysis decision to publish or preparation of the manuscript
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