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Title of Journal: Tumor Biol

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Abbravation: Tumor Biology

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Springer Netherlands

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1423-0380

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The expression of annexin II and Lewis y antigen i

Authors: Huiyu Zhuang Mingzi Tan Juanjuan Liu Xiao Li Jian Gao Zhenhua Hu Lu Deng Liancheng Zhu Bei Lin
Publish Date: 2014/11/22
Volume: 36, Issue: 4, Pages: 2343-2349
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Abstract

The main aim of this study was to explore the molecular structural relationship between annexin II ANXA2 and Lewis y antigen by determining their expression patterns and clinical significance in ovarian epithelial carcinoma The structural relationship between ANXA2 and Lewis y antigen was examined using immunoprecipitation and confocal laser scanning microscopy in two ovarian caner cell lines ES2 and CaoV3 We also constracted the stably transfected cell lines with low ANXA2 gene expression in order to detect the expression level between ANXA2 and Lewis y ANXA2 and Lewis y were detected in tissues from malignant borderline benign and normal ovarian tissues using immunohistochemical analysis ANXA2 and Lewis y were present in both two ovarian cancer cells and ANXA2 contained Lewis y antigen Moreover expression of Lewis y antigen in ANXA2 from cell after transfection was higher than that before Our immunohistochemistry data revealed significantly higher positive expression rates of ANXA2 in malignant ovarian tissues compared to benign tumor and normal tissue similar to Lewis y antigen levels in ovarian cancer Notably tissues displaying marked expression of ANXA2 simultaneously expressed high levels of Lewis y antigen A linear correlation between the expression patterns of ANXA2 and Lewis y antigen was evident Consistently doublelabeling immunofluorescence experiments illustrated colocalization of ANXA2 and Lewis y antigen within the same area In conclusions ANXA2 contains Lewis y antigen Our results further demonstrate a close correlation between the expression levels of the two antigens which are significantly high in ovarian cancerThis work was supported by the National Natural Science Foundation of China Nos 81172491 and 81101527 PhD Programs Foundation of Ministry of Education of China Nos 20112104110016 and 20112104120019 and Shengjing Free Researcher Project No 201303

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