Authors: SungIm Do Dong Hyun Kim JungHo Yang JungSoo Pyo Kyungeun Kim Hyunjoo Lee InGu Do DongHoon Kim Seoung Wan Chae Jin Hee Sohn
Publish Date: 2015/10/07
Volume: 37, Issue: 3, Pages: 3359-3364
Abstract
Cell cycle regulatory proteins including p16 p27 and p53 are well studied in various cancers However their single or concurrent roles related with the clinicopathological parameters are not clearly recognized We analyzed the expression of p16 p27 and p53 cell cycle regulatory proteins in papillary thyroid carcinoma PTC To determine the prognostic significance of cell cycle regulatory proteins 107 PTCs were examined We analyzed the individual expression of p16 p27 and p53 and their concurrent expressions with the relationship to various clinicopathological parameters including differentiation from benign lesions High expression of p16 and p53 and low expression of p27 were related with the distinguishing of PTC from benign lesions In addition normal thyroidal tissue showed higher p27 expression than nodular hyperplasia In relation to extrathyroidal extension ETE the low expression of p27 was related with the presence of ETE The low expression of p27 and high expression of p16 and p53 may affect the development of PTC In addition low p27 expression is related with the existence of ETE
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