Authors: Xiaoli Wei Dongsheng Zhang Mingming He Ying Jin Deshen Wang Yixin Zhou Long Bai Zhezhen Li Huiyan Luo Fenghua Wang Ruihua Xu
Publish Date: 2015/09/01
Volume: 37, Issue: 2, Pages: 1879-1887
Abstract
The elevation of alkaline phosphatase ALP and lactate dehydrogenase LDH has been demonstrated to predict worse prognosis in various malignancies however their prognostic value in esophageal squamous cell carcinoma has not been well studied We conducted a retrospective study of 906 patients with esophageal squamous cell carcinoma to explore their prognostic value for overall survival The optimal cutoff points for ALP and LDH were determined We analyzed the association between the levels of ALP and LDH and clinicopathological characteristics Their prognostic value for overall survival was explored by univariate and multivariate analysis We also proposed the ALP and LDH classification and examined its prognostic value in the general population and subgroups The optimal cutoff points of ALP and LDH to predict overall survival were 907 and 3615 U/L respectively Higher levels of ALP and LDH were both associated with more advanced TNM stage P = 0003 and 0002 respectively and more distant metastasis P = 0001 and P 0001 respectively Both ALP ≤907/907 U/L and LDH ≤3615/3615 U/L were independent prognostic factors for overall survival in esophageal squamous cell carcinoma P = 0004 and P 0001 by multivariate analysis The ALP and LDH classification categorized patients into three subgroups with distinct prognosis P 0001 by multivariate analysis and identified a small group of patients who had extremely poor overall survival with a median of 42 months In conclusion ALP and LDH were both independent prognostic factors for overall survival A combination of the two indexes might contribute to further identification of survival differences in esophageal squamous cell carcinomaThis work was supported by The National Natural Science Foundation of China No 81372570 The Science and Technology Department of Guangdong Province China No 2012B031800088 and The Science and Technology Department of Guangdong Province China No C2011019 We gratefully thank all the staff members in our department for their support and suggestion in this study
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