Authors: Tao Chen Xiaoyu Liu Shanghui Yi Jiannan Zhang Jianwei Ge Zhigang Liu
Publish Date: 2012/11/09
Volume: 34, Issue: 1, Pages: 379-385
Abstract
Glioma is one of the most common solid tumors and the molecular mechanism for this disease is poorly understood EphB4 tyrosine kinase receptor has been involved in various physiologic and pathologic processes and the role of EphB4 in tumorigenesis has recently attracted much interest However its function in glioma remains largely unknown In this study we explored the function of EphB4 in glioma We found that the expression of EphB4 was significantly upregulated in clinical glioma samples Overexpression of EphB4 in glioma cell lines accelerated cell growth and tumorigenesis In contrast downregulation of EphB4 inhibited cell growth Furthermore we showed that EphB4 promoted cell growth by promoting EGFR signaling Taken together our findings suggest that EphB4 plays an important role in the progression of glioma by stimulating cell growth and EphB4 might be a potential therapeutic target for gliomaThis work was supported in part by the key laboratory construction grant no SW201110010 from Science Industry Trade and Information Technology Commission of Shenzhen Municipality and by the grants from the Shanghai Science and Technology Development Fund 10JC1409802 the Scientific Research and Innovation of Shanghai Municipal Education Commission 11YZ50 and the Wu Jieping Medical Foundation 320675011092
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