Authors: Tianqi Li Hongjie Pan Runsheng Li
Publish Date: 2016/07/20
Volume: 37, Issue: 9, Pages: 11667-11677
Abstract
MicroRNAs miRNAs are a group of endogenous small about 22 nucleotides noncoding RNAs which negatively regulate gene expressions As one of them miR204 originates from the sixth intron of the transient receptor potential melastatin 3 TRPM3 gene Therefore expression of miR204 is under the control of the TRPM3 promoter and regulated by genetic and epigenetic mechanisms miR204 has been found to play the important roles in development of eyes and adipogenesis Its pathological functions have been observed in a few diseases including pulmonary arterial hypertension diabetes and various types of cancers It is believed that miR204 acts as a tumorsuppressor via promoting apoptosis conferring the resistance of cancer cells to chemotherapy and suppressing the selfrenewal of cancer stem cells CSCs and the epithelial to mesenchymal transition EMT Expression of miR204 is repressed by its targets XRN1 and TRKB in prostate cancer and endometrial carcinoma respectively therefore they establish an oncogenic feedback loops that play an important role promoting development of cancer In this review we summarize our current knowledge regarding miR204 including its expression regulation and biological functions especially focusing our discussion on its role in tumor development and tumor progression
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