Authors: YuZhou Wang YuSong Han YuShui Ma JunJian Jiang ZiXian Chen YiChao Wang Wu Che Feng Zhang Qing Xia XiaoFeng Wang
Publish Date: 2012/09/01
Volume: 33, Issue: 6, Pages: 2317-2327
Abstract
To gain insight into the role of gene expression alterations in breast cancer progression we conducted a comprehensive gene expression analysis of a series of cell lines derived from MCF10A which include benign MCF10A cells premalignant AT and malignant CA1a tumor cells We analyzed gene expression variation using the Agilent Human Genome Oligo Microarray with the goal of identifying genespecific expression change events In addition to a previously noted overexpression in oncogene MDM2 HRAS and PCNA our studies identified overexpression of Wnt signaling pathway in malignant breast cell lines The Kaplan–Meier plot showed that high cMyc expression in breast cancer was associated with tumor progression and the patient’s poor survival This study showed that the Wnt pathway has further provided a basis for the development of potential biomarker for breast cancer prognosis
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