Authors: ShuHui Liang XiZhang Yan BiaoLuo Wang HaiFeng Jin LiPing Yao YaNi Li Min Chen YongZhan Nie Xin Wang XueGang Guo KaiChun Wu Jie Ding DaiMing Fan
Publish Date: 2013/04/23
Volume: 34, Issue: 5, Pages: 2605-2609
Abstract
Altered expression of forkhead box Q1 FOXQ1 is observed in various types of human cancers However the clinical significance of FOXQ1 expression in gastric cancer GC remains largely unknown The present study aims to explore the clinicopathological significance and prognostic value of FOXQ1 in GC FOXQ1 messenger RNA mRNA and protein expression were determined by quantitative realtime reverse transcriptasepolymerase chain reaction and Western blot in 20 pairs of fresh frozen GC tissues and corresponding noncancerous tissues Additionally FOXQ1 expression was analyzed by immunohistochemistry in 158 clinicopathologically characterized GC cases The correlation of FOXQ1 expression with patients’ survival rate was assessed by Kaplan–Meier and Cox regression Our results showed that the expression levels of FOXQ1 mRNA and protein in GC tissues were both significantly higher than those in noncancerous tissues Our results showed that the high expression of FOXQ1 in GC was related to tumor size P = 0026 histological grade P = 0021 lymph node involvement P = 0002 and tumor–node–metastasis stage P = 0028 Kaplan–Meier survival analysis showed that a high expression level of FOXQ1 resulted in a significantly poor prognosis of GC patients Furthermore Cox multivariates analysis indicated that FOXQ1 expression level was an independent prognostic factor for the overall survival rate of GC patients In conclusion overexpression of FOXQ1 is closely related to progression of GC and might be regarded as an independent predictor of poor prognosis for GC
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