Authors: Wei Chen Siying Zhou Ling Mao Heda Zhang Dawei Sun Junying Zhang JIan Li Jinhai Tang
Publish Date: 2016/05/06
Volume: 37, Issue: 8, Pages: 10011-10019
Abstract
Transforming growth factorβ TGFβ signaling pathway is a key regulator of various cancer biologies including cancer cell migration invasion angiogenesis proliferation as well as apoptosis and it is one of indispensable signaling pathways during cancer metastasis TGFβ signaling pathway can regulate and be regulated by a series of molecular and signaling pathways where microRNAs miRNAs seem to play important roles miRNAs are small noncoding RNAs that can regulate expressions of their target genes Emerging evidence suggest that miRNAs participate in various biological and pathologic processes such as cancer cells apoptosis proliferation invasion migration and metastasis by influencing multiple signaling pathways In this article we focus on the interaction between miRNAs and TGFβ in breast cancer BC metastasis through modulating invasionmetastasisrelated factors including epithelialtomesenchymal transition EMT cancer stem cells CSCs matrix metalloproteinase MMP tissue inhibitors of MMPs TIMPs cell adhesion molecules CAMs and tumor microenvironment TME Through a clear understanding of the complicated links between TGFβ pathway and miRNAs it may provide a novel and safer therapeutic target to prevent BC metastasis
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