Authors: R Jaenisch
Publish Date: 2004/11/01
Volume: 79, Issue: 7, Pages: 1625-1626
Abstract
The paper by Kruse et al published in this issue of Applied Physics A claims that cells isolated from pancreas of adult rats or humans can generate cells of multiple lineages To convincingly show “transdifferentiation” of adult stem cells across lineage boundaries requires stringent experimental criteria such as clonal analyses The data provided by Kruse et al fall short of such standards and the conclusion that multipotential cells were isolated is unconvinving
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