Authors: María J Culzoni Héctor C Goicoechea
Publish Date: 2007/10/23
Volume: 389, Issue: 7-8, Pages: 2217-2225
Abstract
Loratadine LOR and pseudoephedrine sulfate PES were determined in pharmaceutical samples by using nonlinear secondorder data generated by a pHgradient flow injection analysis FIA system with diodearray detection Determination of both analytes was performed on the basis of differences between the acid–base and spectral features of each drug species Nonlinearities were detected by using both qualitative and quantitative tools As a consequence of the nonlinearity a recently reported algorithm artificial neural networks followed by residual bilinearization ANN/RBL was shown to furnish more satisfactory results Recoveries of 997 LOR and 956 PES were obtained when analyzing a validation set containing unexpected components the usual excipients found in pharmaceutical preparations The average value obtained by implementation of the method on four replicates was compared with that obtained by a reference method based on HPLC difference not significant p 005
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