Authors: Zequn Yan Min Xue Qian He Wei Lu Zihui Meng Dan Yan Lili Qiu Lijun Zhou Yingjie Yu
Publish Date: 2016/09/28
Volume: 408, Issue: 29, Pages: 8317-8323
Abstract
A novel polymerized crystalline colloidal array PCCA sensing material for the detection of urine glucose was developed by embedding a twodimensional 2D polystyrene crystalline colloidal array CCA in 3acrylamidophenylboronic acid 3APBAfunctionalized hydrogel After adjusting the crosslinker concentration this material showed significant sensitivity for glucose under lab conditions the particle spacing of the PCCA changed from 917 to 824 nm 93 nm within 3 min as the glucose concentration increased from 0 to 10 mM and the structural color of the PCCA changed from red through orange to green and finally to cyan In further experiments this material was used to semiquantitatively detect glucose in 20 human urine HU samples Compared with the traditional drychemistry method which was applied widely in clinical diagnosis the PCCA method was more accurate and costeffective Moreover this method can efficiently avoid the errors induced by most of the urineinterfering elements like vitamin C and ketone body With a homemade portable optical detector this lowcost intelligent sensing material can provide a more convenient and efficient strategy for the urine glucose detection in clinical diagnosis and pointofcare monitoring
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