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Title of Journal: Anal Bioanal Chem

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Abbravation: Analytical and Bioanalytical Chemistry

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Springer-Verlag

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DOI

10.1007/s10330-011-0754-2

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1618-2650

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Direct analysis of dried blood spots coupled with

Authors: Julien Déglon Aurélien Thomas Patrice Mangin Christian Staub
Publish Date: 2011/06/25
Volume: 402, Issue: 8, Pages: 2485-2498
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Abstract

Because of the emergence of dried blood spots DBS as an attractive alternative to conventional venous plasma sampling in many pharmaceutical companies and clinical laboratories different analytical approaches have been developed to enable automated handling of DBS samples without any pretreatment Associated with selective and sensitive MS–MS detection these procedures give good results in the rapid identification and quantification of drugs generally less than 3 min total run time which is desirable because of the high throughput requirements of analytical laboratories The objective of this review is to describe the analytical concepts of current direct DBS techniques and to present their advantages and disadvantages with particular focus on automation capacity and commercial availability Finally an overview of the different biomedical applications in which these concepts could be of major interest will be presented

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