Authors: Claudia Dietze Tobias Scholl Stefan Ohla Johannes Appun Christoph Schneider Detlev Belder
Publish Date: 2015/09/21
Volume: 407, Issue: 29, Pages: 8735-8743
Abstract
A fast and straightforward method to prototype microfluidic chip systems for deadvolumefree hyphenation to electrosprayionisation mass spectrometry is presented The developed approach based on liquidphase lithography provides an inexpensive and reliable access to microfluidic chips for MS coupling which can be manufactured in any laboratory with low technical demands The rapid prototyping approach enables the seamless integration of capillaries serving as electrospray emitters with negligible dead volume The high versatility of the presented prototyping method and the applicability of a variety of chipbased devices in different fields of labonachip technology are established for analytical separations by means of chipelectrochromatography–MS and for continuousflow synthesis using microreactor technology with MS detection
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