Authors: Daniela A Geraldo Esteban F DuranLara Daniel Aguayo Raul E Cachau Jaime Tapia Rodrigo Esparza Miguel J Yacaman Fernando Danilo GonzalezNilo Leonardo S Santos
Publish Date: 2011/03/05
Volume: 400, Issue: 2, Pages: 483-492
Abstract
Polyamidoamine PAMAM dendrimers and watersoluble 3mercaptopropionic acid MPAcapped CdSe quantum dots QDs were combined to produce a new gel containing supramolecular complexes of QDs/PAMAM dendrimers The formation of the QDs/PAMAM supramolecular complexes was confirmed by high resolution electron microscopy and Fourier transform infrared FTIR analyses Molecular dynamics simulations corroborated the structure of the new QDs/PAMAMbased supramolecular compound Finally on the basis of the prominent fluorescent properties of the supramolecular complexes PAMAM dendrimer was functionalized with folic acid to produce a new QDs/PAMAMfolate derivative that showed an efficient and selective performance as a marker for gastric cancer cellsDAG and LSS thank FONDECYT Postdoctoral Grant 3100037 Proyecto Anillo Científico ACT/24 FDGN and University of Texas at San Antonio MJY for supporting the research activity This work has been funded in part with funds from the NCINIH Contract No HHSN261200800001E The contents of this publication do not necessarily reflect the views or policies of the DHHS nor does mention of trade names commercial products or organizations imply endorsement by the US Government
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