Authors: Luciano Mengatto Julio A Luna María I Cabrera
Publish Date: 2010/02/01
Volume: 45, Issue: 4, Pages: 1046-1051
Abstract
Chitosan membranes were obtained by a casting/solvent evaporation method and crosslinking with sodium tripolyphosphate The effect of crosslinking time was studied and the crosslinked membranes were characterized with respect to equilibrium water content sodium content IR spectroscopy and permeability to a model drug Estradiol Sodium content increased with increasing crosslinking time Equilibrium water content was higher in the membrane with the lowest crosslinking time This membrane also showed a higher flux of Estradiol compared with the other which exhibited an increment in equilibrium water content and flux of Estradiol with the increase in crosslinking duration These dissimilar results could be explained by a significant correlation between the hydrophilicity of the membrane and the hydrophobicity of EstradiolThe authors thank CONICET Consejo Nacional de Investigaciones Científicas y Técnicas and LIF SE Laboratorio Industrial Farmacéutico SEProvincia de Santa Fe for the financial support The authors also thank Susana Gervasio and Ignacio Rintoul for their substantial contributions and technical assistance
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