Authors: Sangeeta Kumari Raj Pal Singh
Publish Date: 2012/10/04
Volume: 48, Issue: 4, Pages: 1524-1532
Abstract
In the present work Co3O4 was prepared by hydrothermal process which is further used for the synthesis of Co3O4–Fe3O4 hybrid nanoparticles The formation of Co3O4–Fe3O4 nanoparticles was investigated by transmission electron microscopy and physical property measurement system In the next step the drugloaded novel nanohybrid porous scaffold based on chitosangglycolic acid and Co3O4–Fe3O4 nanoparticle was prepared by freeze drying technique The grafting of glycolic acid on chitosan drug loading in porous scaffold was characterized by Fourier transform infrared spectroscopy The nanohybrid scaffolds were found to be stable regardless of the pH of the medium and play an important role in cell adhesion proliferation and migration Co3O4–Fe3O4 hybrid nanoparticles reinforcement was found to control the drug cyclophosphamide release rate in phosphate buffer saline solution pH 74 Therefore Co3O4–Fe3O4 hybrid nanoparticles are viable additives for formulating sustained drug delivery systems and could be applied in the field of biomaterialsWe are grateful to Dr Saurav Pal Director National Chemical Laboratory Pune India for his fruitful discussions and suggestions SK is thankful to the Council of Scientific and Industrial Research CSIR New Delhi India for granting junior research fellowship
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