Authors: Faruq Mohammad Hamad A AlLohedan
Publish Date: 2016/07/13
Volume: 51, Issue: 20, Pages: 9207-9216
Abstract
In recent years the Mndoped ZnS quantum dots QDs have been found to be excellent materials for fluorescence imaging of cells and for the detection of molecules such as folic acid acetone etc The fluorescence efficiency of this particular probe is due to the changes occurred in the electronic states of Mn and ZnS by means of doping However this report deals with the negative shades of Mn doping onto ZnS QDs as the formed Mn–ZnS nanocomposite is investigated to produce the Mninduced oxidative stress that can be lethal to the tested cells in vitro For that we first synthesized Mn2+doped ZnS nanocrystals by the coprecipitation method and the physical characterization was performed by means of HRTEM EDAX FTIR XRD and fluorescence spectroscopies Following that we tested for the toxicity effects of Mn–ZnS QDs formed at room temperature by the coprecipitation method with BRL 3A cells of hepatic tissue of rat origin The formed QDs investigated to show significant levels of toxicity toward the cells at 100 µg/mL concentration and over an exposure period of 16 h Further the cells also investigated to generate the reactive oxygen species which is further responsible for the fragmentation of DNA and reduction in mitochondrial transmembrane potentials From the analysis of results we believe that this report of its kind provides a preliminary piece of information toward the designing and applicability of Mncontaining compounds to biomedical sector due to its severe oxidative stress effect
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